Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating.

  title={Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating.},
  author={Mark L. Chapman and Hendrika M Vandongen and Antonius M. J. VanDongen},
  journal={Biophysical journal},
  volume={72 2 Pt 1},
Ion permeation and channel opening are two fundamental properties of ion channels, the molecular bases of which are poorly understood. Channels can exist in two permeability states, open and closed. The relative amount of time a channel spends in the open conformation depends on the state of activation. In voltage-gated ion channels, activation involves movement of a charged voltage sensor, which is required for channel opening. Single-channel recordings of drk1 K channels expressed in Xenopus… CONTINUE READING

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