Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.

@article{Hutchcroft1994ActivationdependentPO,
  title={Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.},
  author={Jill E. Hutchcroft and Barbara E Bierer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 8},
  pages={3260-4}
}
CD28 is a costimulatory receptor that can provide the second signal necessary for T-cell activation and function in response to stimulation through the T-cell antigen receptor/CD3 complex. We found that a distinct array of proteins was phosphorylated on tyrosine following stimulation with anti-CD28 monoclonal antibody, as detected by immune-complex kinase assays. Anti-CD28 stimulation of in vitro kinase activity was detergent-dependent, occurring in immune complexes prepared with Brij 96 but… CONTINUE READING

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