Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception.

@article{Raisinghani2011ActivationCO,
  title={Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception.},
  author={Manish Raisinghani and Linlin Zhong and Joseph A. Jeffry and Mahendra Bishnoi and Reddy M. Pabbidi and F{\'a}tima Pimentel and De-Shou Cao and Miles Steven Evans and Louis S. Premkumar},
  journal={American journal of physiology. Cell physiology},
  year={2011},
  volume={301 3},
  pages={C587-600}
}
Transient receptor potential (TRP) ankyrin 1 (TRPA1) is a Ca(2+)-permeant, nonselective cationic channel. It is predominantly expressed in the C afferent sensory nerve fibers of trigeminal and dorsal root ganglion neurons and is highly coexpressed with the nociceptive ion channel transient receptor potential vanilloid 1 (TRPV1). Several physical and chemical stimuli have been shown to activate the channel. In this study, we have used electrophysiological techniques and behavioral models to… CONTINUE READING

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ACTIVATION CHARACTERISTICS OF TRPA1 AJP-Cell Physiol

  • W Everaerts, M Gees, +8 authors B Nilius
  • Curr Biol
  • 2011
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