Activation by acetaldehyde of the promoter of the mouse alpha2(I) collagen gene when transfected into rat activated stellate cells.

@article{Anania1996ActivationBA,
  title={Activation by acetaldehyde of the promoter of the mouse alpha2(I) collagen gene when transfected into rat activated stellate cells.},
  author={Frank A Anania and James M. Potter and Lynda Rennie-Tankersley and Esteban Mezey},
  journal={Archives of biochemistry and biophysics},
  year={1996},
  volume={331 2},
  pages={187-93}
}
The effect of acetaldehyde in activating the mouse alpha2(I) collagen promoter in transiently transfected rat activated stellate cells and the possible mediating effect of transforming growth factor beta1 (TGFbeta1) on type I collagen gene expression were determined. Acetaldehyde and TGFbeta1, each had a similar effect in activating the wild-type promoter, but failed to activate the promoter with a -352 to -104 deletion, or the promoter containing a 3-bp substitution between -305 and -303 in… CONTINUE READING

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