Activation by P2X7 agonists of two phospholipases A2 (PLA2) in ductal cells of rat submandibular gland. Coupling of the calcium-independent PLA2 with kallikrein secretion.

Abstract

Isolated ductal cells of rat submandibular gland phospholipid pools were labeled with [3H]arachidonic acid (AA). The tracer was incorporated preferentially to phosphatidylcholine (46% of the lipidic fraction). Extracellular ATP induced the release of [3H]AA to the extracellular medium in a time- and dose-dependent manner (EC50 = 220 microM). Among other… (More)

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@article{Alzola1998ActivationBP, title={Activation by P2X7 agonists of two phospholipases A2 (PLA2) in ductal cells of rat submandibular gland. Coupling of the calcium-independent PLA2 with kallikrein secretion.}, author={E S Alzola and A P{\'e}rez-Etxebarria and Elie Kabr{\'e} and David J. Fogarty and Mourad M{\'e}tioui and N Cha{\"{i}b and Jos{\'e} Mar{\'i}a Macarulla and Carlos Matute and J. P. Dehaye and Aida Marino}, journal={The Journal of biological chemistry}, year={1998}, volume={273 46}, pages={30208-17} }