Activation by N‐Acetyl‐l‐Aspartate of Acutely Dissociated Hippocampal Neurons in Rats via Metabotropic Glutamate Receptors

@article{Yan2003ActivationBN,
  title={Activation by N‐Acetyl‐l‐Aspartate of Acutely Dissociated Hippocampal Neurons in Rats via Metabotropic Glutamate Receptors},
  author={Hai-Dun Yan and Kumatoshi Ishihara and Tadao Serikawa and Masashi Sasa},
  journal={Epilepsia},
  year={2003},
  volume={44}
}
Summary:  Purpose: We previously reported that an increase in the N‐acetyl‐l‐aspartate (NAA) level due to the lack of aspartoacylase gene was found in the brain of the tremor rat (tm/tm), which is a mutant with a causative gene named tm that shows epileptic seizures. Therefore, NAA is suggested to be one of the factors involved in the induction of epileptic seizures. Patch‐clamp studies were performed to determine whether NAA produces an excitatory effect on acutely dissociated rat hippocampal… Expand
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