Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

  title={Activation by IKK$\alpha$ of a Second, Evolutionary Conserved, NF-$\kappa$B Signaling Pathway},
  author={Uwe Senftleben and Yixue Cao and Gutian Xiao and Florian R. Greten and Gertraud Krähn and Giuseppina Bonizzi and Yi Chen and Yinling Hu and Abraham Fong and Shao-Cong Sun and Michael Karin},
  pages={1495 - 1499}
In mammals, the canonical nuclear factor κB (NF-κB) signaling pathway activated in response to infections is based on degradation of IκB inhibitors. This pathway depends on the IκB kinase (IKK), which contains two catalytic subunits, IKKα and IKKβ. IKKβ is essential for inducible IκB phosphorylation and degradation, whereas IKKα is not. Here we show that IKKα is required for B cell maturation, formation of secondary lymphoid organs, increased expression of certain NF-κB target genes, and… 
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