Activation by ACA Induces Pluripotency in Human Blood Progenitor Cells

  title={Activation by ACA Induces Pluripotency in Human Blood Progenitor Cells},
  author={Z. A. Becker-Koji{\'c} and Juan R. Ure{\~n}a-Peralta and Iv{\'a}n Zipancic and F. J. Rodriguez-Jim{\'e}nez and M. P. Rubio and Petra Stojkovic and Mireia G{\'a}rcia Rosell{\'o} and Miodrag Stojkovic},
  journal={Bulletin of Experimental Biology and Medicine},
Reprogramming of human somatic cells by transcription factors to pluripotent state holds great promise for regenerative medicine. However, low efficiencies of current reprogramming methods, immunogenicity and lack of understanding regarding the molecular mechanisms responsible for their generation, limits their utilization and raises questions regarding safety for therapeutic application. Here we report that ACA signaling via PI3K/Akt/mTor induces sustained de-differentiation of human blood… 



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