Activation and transforming growth factor-beta production in eosinophils by hyaluronan.

@article{Ohkawara2000ActivationAT,
  title={Activation and transforming growth factor-beta production in eosinophils by hyaluronan.},
  author={Yuichi Ohkawara and Gen Tamura and Takao Iwasaki and Aya Tanaka and Tadashi Kikuchi and Kunio Shirato},
  journal={American journal of respiratory cell and molecular biology},
  year={2000},
  volume={23 4},
  pages={
          444-51
        }
}
To investigate whether extracellular matrix glycosaminoglycan hyaluronan (HA) modulates eosinophil activation and transforming growth factor (TGF)-beta production by eosinophils, human peripheral blood eosinophils (purity > 99%) from 12 patients with mild to moderate asthma or six healthy subjects were isolated and incubated with increasing concentrations of low molecular weight (mol wt) HA ( approximately 0.2 x 10(6) D) or high mol wt HA (3.0 to approximately 5.8 x 10(6) D). We found that the… 
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The roles of HA interactions with CD44 and RHAMM in inflammatory responses and tumor development/progression are described, and how therapeutic strategies that block these key inflammatory/tumorigenic processes may be developed in rodent and human diseases are described.
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Analysis of processes involved in HA synthesis, deposition and localization during the propagation of cockroach-induced asthma and data support a role for HA in the pathogenesis in asthma.
Signaling Properties of Hyaluronan Receptors*
TLDR
The study of murine cardiac cells derived from hyaluronan synthase 2 (HAS2) knockout mice has provided the most convincing evidence for a signaling capability of hyAluronan, and results suggest that hy aluronan signals through Ras to regulate motility are consistent with previous studies showing that exogenous hyaltonanreceptor interactions regulate Ras signaling.
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The results suggest that in this murine asthma model, the SHAP-HA complex has an inhibitory role in the development of airway hyperresponsiveness and allergic airway inflammation which may be attributed, at least in part, to negative feedback mechanisms exerted by sTNFR1.
Hyaluronan deposition and co-localization with inflammatory cells and collagen in a murine model of fungal allergic asthma
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Evidence of HA localization in fungal allergic asthma provides the impetus to study HA more closely with allergic leukocytes in murine models, and contributes to the growing literature that focuses on the components of ECM as inflammatory mediators rather than mere structural support products.
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