Activation and subsequent degradation of proacrosin is mediated by zona pellucida glycoproteins, negatively charged polysaccharides, and DNA.

@article{Eberspaecher1991ActivationAS,
  title={Activation and subsequent degradation of proacrosin is mediated by zona pellucida glycoproteins, negatively charged polysaccharides, and DNA.},
  author={Uwe Eberspaecher and Jens Gerwien and Ursula F Habenicht and W. D. Schleuning and Peter Donner},
  journal={Molecular reproduction and development},
  year={1991},
  volume={30 2},
  pages={164-70}
}
Boar proacrosin (E.C. 3.4.21.10, Mw 53 kD) was isolated by a modified method and subjected to autoactivation. Previously described molecular intermediates of 49 and 43 kD and a stable form (beta-acrosin, 35 kD) were identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Autoactivation was expedited in the presence of either zona pellucida glycoproteins, fucoidan, or DNA. The end point of this accelerated conversion was the complete degradation of otherwise stable beta-acrosin… CONTINUE READING

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