Activation and self-tolerance of natural killer cells.

  title={Activation and self-tolerance of natural killer cells.},
  author={Stephan Gasser and David H Raulet},
  journal={Immunological reviews},
Natural killer (NK) cells are regulated by numerous stimulatory and inhibitory receptors that recognize various classes of cell surface ligands, some of which are expressed by normal healthy cells. We review two key issues in NK cell biology. How do NK cells achieve tolerance to healthy self-cells, despite great potential variability in inhibitory and stimulatory receptor engagement? How is the disease status of unhealthy cells translated into changes in ligand expression and consequent… CONTINUE READING

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