Activation and repression of the 2-5A synthetase and p21 gene promoters by IRF-1 and IRF-2

@article{Coccia1999ActivationAR,
  title={Activation and repression of the 2-5A synthetase and p21 gene promoters by IRF-1 and IRF-2},
  author={Eliana M Coccia and Nicoletta Del Russo and Emilia Stellacci and Roberto Orsatti and Eleonora Benedetti and Giovanna Marziali and John Hiscott and Angela Battistini},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={2129-2137}
}
The Interferon Regulatory Factors-1 and -2 (IRF-1 and IRF-2) were originally identified as transcriptional regulators of the interferon (IFN) and IFN-stimulated genes. These factors also modulate immune response and play a role in cell growth regulation. In this study we analysed the effect of the ectopic expression of IRF-1 and IRF-2 on the regulation of two potential IRF target genes involved in cell growth regulation, 2-5A synthetase and p21 (WAF/CP1), both of which contain consensus binding… CONTINUE READING