Activation and regulation of store-operated calcium entry

  title={Activation and regulation of store-operated calcium entry},
  author={Jeremy T. Smyth and Sung-Yong Hwang and Takuro Tomita and Wayne I Dehaven and Jason C Mercer and James W Putney},
  booktitle={Journal of cellular and molecular medicine},
The process of store-operated Ca(2+) entry (SOCE), whereby Ca(2+) influx across the plasma membrane is activated in response to depletion of intracellular Ca(2+) stores in the endoplasmic reticulum (ER), has been under investigation for greater than 25 years; however, only in the past 5 years have we come to understand this mechanism at the molecular level. A surge of recent experimentation indicates that STIM molecules function as Ca(2+) sensors within the ER that, upon Ca(2+) store depletion… CONTINUE READING

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STIM1 carboxyl-terminus activates native SOC, No claim to original US government works Journal compilation © 2010 Foundation for Cellular and Molecular Medicine/Blackwell

  • GN Huang, W Zeng, JY Kim
  • Publishing Ltd J. Cell. Mol. Med
  • 2010
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