Activation and involvement of p53 in cisplatin-induced nephrotoxicity.

@article{Wei2007ActivationAI,
  title={Activation and involvement of p53 in cisplatin-induced nephrotoxicity.},
  author={Qingqing Wei and Guie Dong and Tianxin Yang and Judit 4 Megyesi and Peter M. Price and Zheng Dong},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 4},
  pages={F1282-91}
}
Cisplatin, a widely used chemotherapy drug, induces acute kidney injury, which limits its use and efficacy in cancer treatment. However, the molecular mechanism of cisplatin-induced nephrotoxicity is currently unclear. Using pharmacological and gene knockout models, we now demonstrate a pathological role for p53 in cisplatin nephrotoxicity. In C57BL/6 mice, cisplatin treatment induced p53 phosphorylation and protein accumulation, which was accompanied by the development of acute kidney injury… CONTINUE READING

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