Activation and inhibition of the human α7 nicotinic acetylcholine receptor by agonists

@article{Briggs1998ActivationAI,
  title={Activation and inhibition of the human $\alpha$7 nicotinic acetylcholine receptor by agonists},
  author={Clark A. Briggs and D. G. Mckenna},
  journal={Neuropharmacology},
  year={1998},
  volume={37},
  pages={1095-1102}
}
To better understand the effects of weak as well as strong agonists at the human alpha7 nicotinic acetylcholine receptor (human alpha7 nAChR), the abilities of several classic nAChR agonists to both activate and inhibit (desensitize) the human alpha7 nAChR expressed in Xenopus oocytes were quantified and compared. Activation was measured during 0.2-20 s agonist application, as required to elicit a peak response. Inhibition was measured as the reduction in the agonist response to 200 microM ACh… Expand
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