Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin.

@article{MoogLutz2005ActivationAI,
  title={Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin.},
  author={Christel Moog-Lutz and Joffrey L. Degoutin and Jean Y Gouzi and Yvelyne Frobert and Nicole Brunet-de Carvalho and Jocelyne Bureau and Christophe A Cr{\'e}minon and Marc Vigny},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 28},
  pages={26039-48}
}
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that is transiently expressed in specific regions of the central and peripheral nervous systems, suggesting a role in its normal development and function. The nature of the cognate ligands of ALK in vertebrate is still a matter of debate. We produced a panel of monoclonal antibodies (mAbs) directed against the extracellular domain of the human receptor. Two major species of ALK (220 and 140 kDa) were identified in transfected cells… CONTINUE READING
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