Activation and inhibition of ATP-sensitive K+ channels by fluorescein derivatives.

@article{Weille1992ActivationAI,
  title={Activation and inhibition of ATP-sensitive K+ channels by fluorescein derivatives.},
  author={J R de Weille and Melanie M{\"u}ller and Michael Lazdunski},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 7},
  pages={4557-63}
}
Fluorescein derivatives are known to bind to nucleotide-binding sites on transport ATPases. In this study, they have been used as ligands to nucleotide-binding sites on ATP-sensitive K+ channels in insulinoma cells. Their effect on channel activity has been studied using 86Rb+ efflux and patch-clamp techniques. Fluorescein derivatives have two opposite effects. First, like ATP, they can inhibit active ATP-sensitive K+ channels. Second, they are able to reactivate ATP-sensitive K+ channels… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…