Activation and inactivation of neocarzinostatin-induced cleavage of DNA.

@article{Kappen1978ActivationAI,
  title={Activation and inactivation of neocarzinostatin-induced cleavage of DNA.},
  author={Lizzy S. Kappen and I. H. Goldberg},
  journal={Nucleic acids research},
  year={1978},
  volume={5 8},
  pages={2959-67}
}
The possible role of free radicals in the mechanism of neocarzinostatin (NCS) action was studied. While mercaptene markedly stimulate the ability of NCS to degrade DNA, they also rapidly inactivate the antibiotic in a preincubation and at higher concentration inhibit the degradation reaction. The radiation protector S,2-aminoethylisothiuronium bromide-HBr… CONTINUE READING