Activation and growth of murine tumor-specific T-cells which have in vivo activity with bryostatin 1.

@article{Tuttle1992ActivationAG,
  title={Activation and growth of murine tumor-specific T-cells which have in vivo activity with bryostatin 1.},
  author={Todd M. Tuttle and Thomas H. Inge and Kevin P. Bethke and Carl W. McCrady and George R. Pettit and Harry D Bear},
  journal={Cancer research},
  year={1992},
  volume={52 3},
  pages={548-53}
}
We examined the ability of bryostatin 1 (Bryo), a novel protein kinase C activator, plus ionomycin (Io), a calcium ionophore, to activate T-cells with specific antitumor activity. Lymphocytes from the draining lymph nodes (DLN) of MCA-105 tumor-bearing host mice were stimulated with Bryo/Io, either fresh or after in vitro stimulation with autologous tumor, and then were incubated in interleukin-2 at 20 units/ml. Lymphocytes sensitized with tumor cells in vitro and then stimulated with Bryo/Io… CONTINUE READING
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Bryostatin generates T cells with antitumor activity

  • T. M. Tuttle, T. H. Inge, K. P. Bethke, C. W. McCrady, H. D. Bear
  • Surg. Forum,
  • 1991
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