Activation and expansion of cytotoxic T lymphocytes from tumor-draining lymph nodes

@article{McKinnon1990ActivationAE,
  title={Activation and expansion of cytotoxic T lymphocytes from tumor-draining lymph nodes},
  author={J. Gregory McKinnon and Shelley K. Hoover and Thomas H. Inge and Harry D. Bear},
  journal={Cancer Immunology, Immunotherapy},
  year={1990},
  volume={32},
  pages={38-44}
}
SummaryLarge numbers of cytotoxic T lymphocytes (CTL) could be generated from tumor-draining lymph nodes (DLN) from mice bearing PHS-5 tumor by culturing at low density with autologous tumor cell stimulators and 20 U/ml recombinant interleukin-2 (IL-2). Outgrowth of metastatic tumor cells in culture was prevented by use of this hypoxanthine/aminopterin/thymidine-sensitive mutant of P815, PHS-5. After 9 days in culture, lymphoid cells demonstrated specific cytotoxicity against autologous tumor… CONTINUE READING

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