Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology

@inproceedings{Zhang2015ActivationAE,
  title={Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology},
  author={Yonghe Zhang and Huiming Huang and Shanshan Xu and Bo Wang and Jianhua Ju and Huarong Tan and Wenli Li},
  booktitle={Microbial Cell Factories},
  year={2015}
}
BackgroundMarine microorganisms are an important source of new drug leads. However, the discovery and sustainable production of these compounds are often hampered due to the unavailable expression of cryptic biosynthetic gene clusters or limited titer. Ribosome engineering and response surface methodology (RSM) integrated strategy was developed in this study to activate cryptic gene cluster in the deepsea-derived Streptomyces somaliensis SCSIO ZH66, and subsequently isolation, structural… CONTINUE READING
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