Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine.

@article{Papke2009ActivationAD,
  title={Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine.},
  author={Roger L Papke and William R. Kem and Ferenc Soti and Gretchen Y. L{\'o}pez-Hern{\'a}ndez and Nicole A Horenstein},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={329 2},
  pages={
          791-807
        }
}
Nicotinic receptor activation is inextricably linked to desensitization. This duality affects our ability to develop useful therapeutics targeting nicotinic acetylcholine receptor (nAChR). Nicotine and some alpha7-selective experimental partial agonists produce a transient activation of alpha7 receptors followed by a period of prolonged residual inhibition or desensitization (RID). The object of the present study was to determine whether RID was primarily due to prolonged desensitization or due… CONTINUE READING

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