Activation and desensitization by cyclic antidepressant drugs of α2-autoreceptors, α2-heteroreceptors and 5-HT1A-autoreceptors regulating monoamine synthesis in the rat brain in vivo

@article{Esteban1999ActivationAD,
  title={Activation and desensitization by cyclic antidepressant drugs of $\alpha$2-autoreceptors, $\alpha$2-heteroreceptors and 5-HT1A-autoreceptors regulating monoamine synthesis in the rat brain in vivo},
  author={S. Esteban and J. Llad{\'o} and A. Sastre-Coll and J. Garc{\'i}a-Sevilla},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1999},
  volume={360},
  pages={135-143}
}
Abstract. The effects of antidepressant drugs on the synthesis of noradrenaline and serotonin (5-HT) were assessed using the accumulation of 3,4-dihydroxyphenylalanine (dopa) and 5-hydroxytryptophan (5-HTP) after decarboxylase inhibition as a measure of the rate of tyrosine and tryptophan hydroxylation in the rat brain in vivo. Three inhibitory synthesis-modulating receptors were investigated simultaneously: the α2C-autoreceptor modulating dopa/noradrenaline synthesis, and the α2A… Expand
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