Activation and dedifferentiation of chondrocytes: implications in cartilage injury and repair.

@article{SchulzeTanzil2009ActivationAD,
  title={Activation and dedifferentiation of chondrocytes: implications in cartilage injury and repair.},
  author={Gundula G. Schulze-Tanzil},
  journal={Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft},
  year={2009},
  volume={191 4},
  pages={325-38}
}
Cartilage injury remains a major challenge in orthopedic surgery due to the fact that articular cartilage has only a limited capacity for intrinsic healing. Cartilage impaction is followed by a post-traumatic inflammatory response. Chondrocytes and synoviocytes are activated to produce inflammatory mediators and degradative enzymes which can induce a progradient cartilage self-destruction finally leading to secondary osteoarthritis (OA). However, an anti-inflammatory compensatory response is… CONTINUE READING
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