Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice

  title={Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice},
  author={C. Morton and Lisa Iacono and Janice L. Hyatt and Kody R. Taylor and Pamela J. Cheshire and Peter James Houghton and Mary K. Danks and Clinton F Stewart and Philip G. Potter},
  journal={Cancer Chemotherapy and Pharmacology},
Purpose: To examine the antitumor activity and the pharmacokinetics of CPT-11 (irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin) in a plasma esterase-deficient scid mouse model, bearing human tumor xenografts. Experimental design: Plasma carboxylesterase (CE)-deficient mice were bred with scid animals to develop a strain that would allow growth of human tumor xenografts. Following xenotransplantation, the effect of the plasma esterase on antitumor activity… CONTINUE READING
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Metabolism of CPT-11 in esterase deficient mice

  • CL Morton, KR Taylor, +5 authors PM Potter
  • Proc Am Assoc Cancer Res
  • 2002
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