Activation and Specificity of Aflatoxin B 1 Binding on hhc M , a Human Oncogene of Low Efficiency, and Cell Transformation

@inproceedings{Yang1990ActivationAS,
  title={Activation and Specificity of Aflatoxin B 1 Binding on hhc M , a Human Oncogene of Low Efficiency, and Cell Transformation},
  author={STRINGNER S. Yang and Ke Zhang and George C. Yang and Janet Taub},
  year={1990}
}
Aflatoxin B1 (AFB1), a metabolite of Aspergillus flavus, chemically classified as a furocoumarin, is known to be the most potent hepatocarcinogen experimentally tested in various species including trout, rat, hamster, dog and rhesus monkey.13,21 The carcinogenic effect resides in the mutagenic potential of AFB1 upon metabolic conversion into the epoxide form by liver mixed function oxidases. By mode of nucleophilic attack, AFB1-epoxide binds to DNA forming covalent bonds with the N7 of… 

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TLDR
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