Activation-Induced T Helper Cell Death Contributes to Th1/Th2 Polarization following Murine Schistosoma japonicum Infection

@inproceedings{Xu2010ActivationInducedTH,
  title={Activation-Induced T Helper Cell Death Contributes to Th1/Th2 Polarization following Murine Schistosoma japonicum Infection},
  author={Xinyu Xu and Xiaoyun Wen and Ying Chi and Lei He and Sha Zhou and Xuefeng Wang and Jiaqing Zhao and Feng Liu and Chuan Su},
  booktitle={Journal of biomedicine & biotechnology},
  year={2010}
}
In chronic infectious diseases, such as schistosomiasis, pathogen growth and immunopathology are affected by the induction of a proper balanced Th1/Th2 response to the pathogen and by antigen-triggered activation-induced T cell death. Here, by using S. japonicum infection or schistosome antigens-immunized mouse model, or antigens in vitro stimulation, we report that during the early stage of S. japonicum infection, nonegg antigens trigger Th2 cell apoptosis via the granzyme B signal pathway… CONTINUE READING
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