Activation-Induced Inhibition of Interleukin 6–Mediated T Cell Survival and Signal Transducer and Activator of Transcription 1 Signaling

@article{Teague2000ActivationInducedIO,
  title={Activation-Induced Inhibition of Interleukin 6–Mediated T Cell Survival and Signal Transducer and Activator of Transcription 1 Signaling},
  author={T Kent Teague and Brian C Schaefer and David A Hildeman and Jeremy Bender and Tom Mitchell and John W Kappler and Philippa Marrack},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={191},
  pages={915 - 926}
}
The cytokines interleukin (IL)-2, IL-4, IL-6, IL-7, and IL-15 have all previously been shown to inhibit resting T cell death in vitro. We have found a difference in the response of T cells to IL-6, depending on the activation status of the cells. IL-6 inhibited the death of naive T cells, but had no effect on the death of either superantigen-activated T cells, or T cells bearing memory markers. This was true even when the resting and activated T cells were isolated from the same animal; thus… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 44 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 68 REFERENCES

Cytokine-induced survival of activated T cells in vitro and in vivo.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
VIEW 4 EXCERPTS