Activation-Induced Apoptosis of Peripheral Lymphocytes Treated with 7-Hydroxystaurosporine, UCN-01

Abstract

7-hydroxystaurosporine (UCN-01) is a new anticancer agentwhich exerts an inhibitory effect on cell cycle check points andis currently under phase I clinical trials in US and Japan.Preliminary clinical data indicated that UCN-01 remained inplasma at high concentrations for long periods of time. Thisunavoidable high plasma drug exposure is likely to lead… (More)
DOI: 10.1023/A:1006374118879

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Cite this paper

@article{Fukumoto1999ActivationInducedAO, title={Activation-Induced Apoptosis of Peripheral Lymphocytes Treated with 7-Hydroxystaurosporine, UCN-01}, author={Hisao Fukumoto and Tomohide Tamura and Yoshikazu Kamiya and Jitsuo Usuda and Toshihiro Suzuki and Fumihiko Kanzawa and Hyo-Jeong Kuh and Yuichiro Ohe and Nagahiro George Saijo and Kazuto Nishio}, journal={Investigational New Drugs}, year={1999}, volume={17}, pages={335-341} }