Activation, regulation, and inhibition of DYRK1A.

  title={Activation, regulation, and inhibition of DYRK1A.},
  author={Walter Becker and Wolfgang Sippl},
  journal={The FEBS journal},
  volume={278 2},
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a protein kinase with diverse functions in neuronal development and adult brain physiology. Higher than normal levels of DYRK1A are associated with the pathology of neurodegenerative diseases and have been implicated in some neurobiological alterations of Down syndrome, such as mental retardation. It is therefore important to understand the molecular mechanisms that control the activity of DYRK1A. Here we review the… CONTINUE READING