Activation, proliferation and commitment of endogenous stem/progenitor cells to the oligodendrocyte lineage by TS1 in a rat model of dysmyelination.

@article{EspinosaJeffrey2006ActivationPA,
  title={Activation, proliferation and commitment of endogenous stem/progenitor cells to the oligodendrocyte lineage by TS1 in a rat model of dysmyelination.},
  author={Araceli Espinosa-Jeffrey and Paul Song Bo Zhao and Wole Awosika and Nanping Wu and Fernando Mac{\'i}as and Carlos Cepeda and Michael Levine and Jean de Vellis},
  journal={Developmental neuroscience},
  year={2006},
  volume={28 6},
  pages={
          488-98
        }
}
Wild-type and myelin-deficient rats received a single intraparenchymal injection of TS1, a specific combination of IGF-1 and transferrin (Tf), into their corpus callosum at postnatal day 4. The fate of endogenous stem cells in the brain was examined by the expression of the stem cell marker nestin, together with Tf, neurofilaments and glial fibrillary acidic protein from 2 to 14 days after injection. Treated mutants lacked nestin expression in the ventricular wall and had an increase in nestin… CONTINUE READING

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