Activation, activity and inactivation of factor VIII in factor VIII products.

Abstract

INTRODUCTION Factor VIII (FVIII) products used in haemophilia A treatment show inter-and intra-product and inter-assay differences in specific activity. The mechanistic basis of these differences remains unclear. AIM The aim of this study was to mechanistically compare the functional properties of an in-house excipient-free full-length FVIII standard and… (More)
DOI: 10.1111/hae.12872

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