Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease.

@article{Naranjo2016ActivatingTF,
  title={Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease.},
  author={Jose R Naranjo and Hongyu Zhang and D. Santos Villar and Paz L. Gonz{\'a}lez and Xos{\'e} M. Dopazo and Javier Mor{\'o}n-Oset and Elena Higueras and Juan C. Oliveros and Mar{\'i}a D Arrabal and Angela Prieto and Pilar Cerc{\'o}s and Teresa Gonz{\'a}lez and Alicia de la Cruz and Juan Casado-Vela and Alberto R{\'a}bano and Carmen M. Valenzuela and Marta Guti{\'e}rrez-Rodr{\'i}guez and Jia-yi Li and Britt Mellstr{\"o}m},
  journal={The Journal of clinical investigation},
  year={2016},
  volume={126 2},
  pages={627-38}
}
Deregulated protein and Ca2+ homeostasis underlie synaptic dysfunction and neurodegeneration in Huntington disease (HD); however, the factors that disrupt homeostasis are not fully understood. Here, we determined that expression of downstream regulatory element antagonist modulator (DREAM), a multifunctional Ca2+-binding protein, is reduced in murine in vivo and in vitro HD models and in HD patients. DREAM downregulation was observed early after birth and was associated with endogenous… CONTINUE READING