Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification

@article{Duan2013ActivatingTF,
  title={Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification},
  author={Xiao-hui Duan and Jin-rui Chang and Jing Zhang and Baohong Zhang and Yulin Li and X U Teng and Yi Zhu and Jie Du and Chao-shu Tang and Yong-fen Qi},
  journal={Apoptosis},
  year={2013},
  volume={18},
  pages={1132-1144}
}
Our previous work reported that endoplasmic reticulum stress (ERS)-mediated apoptosis was activated during vascular calcification (VC). Activating transcription factor 4 (ATF4) is a critical transcription factor in osteoblastogenesis and ERS-induced apoptosis. However, whether ATF4 is involved in ERS-mediated apoptosis contributing to VC remains unclear. In the present study, in vivo VC was induced in rats by administering vitamin D3 plus nicotine. Vascular smooth muscle cell (VSMC… CONTINUE READING

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