Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination.

@article{Yan2005ActivatingTF,
  title={Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination.},
  author={Chunhong Yan and Dan Lu and Tsonwin Hai and Douglas David. Boyd},
  journal={The EMBO journal},
  year={2005},
  volume={24 13},
  pages={
          2425-35
        }
}
Activating transcription factor 3 (ATF3) is rapidly induced by diverse environmental insults including genotoxic stress. We report herein that its interaction with p53, enhanced by genotoxic stress, stabilizes the tumor suppressor thereby augmenting functions of the latter. Overexpression of ATF3 (but not a mutated ATF3 protein (Delta102-139) devoid of its p53-binding region) prevents p53 from MDM2-mediated degradation and leads to increased transcription from p53-regulated promoters. ATF3, but… CONTINUE READING
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