Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes.

@article{Beier2000ActivatingTF,
  title={Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes.},
  author={Frank M. Beier and Allison C. Taylor and P A Luvalle},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 17},
  pages={12948-53}
}
Endochondral bone growth is regulated through the proliferation and differentiation of growth plate chondrocytes. Mice deficient for the activating transcription factor 2 (ATF-2) gene show reduced proliferation of chondrocytes. Here we demonstrate that the cyclin A gene is a target of ATF-2 in chondrocytes. Serum stimulation of chondrogenic rat chondrosarcoma cells induces cyclin A expression. A cyclic AMP response element (CRE) is necessary for optimal activity and serum inducibility of the… CONTINUE READING

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