Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation.

Abstract

Increased intracellular cAMP and Ca2+ levels can activate transcription of a number of eukaryotic genes through a common promoter element, the cAMP/Ca2+ response element. This element is the binding site for activating transcription factor (ATF)/CREB proteins, an extensive transcription factor family. Here we report that one member of this family, ATF-1… (More)

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