Activating the Wnt/β-Catenin Pathway Did Not Protect Immature Retina from Hypoxic-Ischemic Injury.

@article{Huang2015ActivatingTW,
  title={Activating the Wnt/β-Catenin Pathway Did Not Protect Immature Retina from Hypoxic-Ischemic Injury.},
  author={H C Huang and Chao-Ching Huang and F. S. Wang and Pi-Liang Hung and Y. C. Chang},
  journal={Investigative ophthalmology & visual science},
  year={2015},
  volume={56 8},
  pages={4300-8}
}
PURPOSE Visual loss associated with hypoxic-ischemic (HI) brain damage is the most common cause of visual impairment in children of developed countries. A neuroprotective role for Wnt/β-catenin signaling has been demonstrated in several neurodegenerative disorders. The association of Wnt signaling with HI injury in immature retina has not been established. METHODS On postnatal day 7 (P7), HI was induced by unilateral common carotid artery ligation followed by 8% oxygen hypoxia for 2 hours… CONTINUE READING
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