Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats.

@article{Fan2013ActivatingTN,
  title={Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats.},
  author={Xian Lin Fan and Bashar S. Staitieh and J Spencer Jensen and Kara J Mould and Jared A Greenberg and Pratibha C. Joshi and Michael Koval and David M. Guidot},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2013},
  volume={305 3},
  pages={
          L267-77
        }
}
The master transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) regulates the expression of antioxidant and phase II-metabolizing enzymes by activating the antioxidant response element (ARE) and thereby protects cells and tissues from oxidative stress. Pulmonary complications remain the leading cause of death in human immunodeficiency virus (HIV)-1-infected individuals, who display systemic oxidative stress and glutathione deficiency that can be modeled in transgenic rats… CONTINUE READING

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