Activating silent Argonautes

  title={Activating silent Argonautes},
  author={Mary Anne Kidwell and Jennifer A. Doudna},
  journal={Nature Structural &Molecular Biology},
Multiple Argonaute proteins are implicated in gene silencing by RNA interference (RNAi), but only one is known to be an endonuclease that can cleave target mRNAs. Chimeric Argonaute proteins now reveal an unexpected mechanism by which mutations distal to the catalytic center can unmask intrinsic catalytic activity, results hinting at structurally mediated… CONTINUE READING