Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.

@article{Kim2003ActivatingSC,
  title={Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.},
  author={Seung-Whan Kim and Keunhee Park and Eunyee Kwak and Eunho Choi and Seunghee Lee and Jungyeob Ham and Heonjoong Kang and Jong Man Kim and Seung Yong Hwang and Young-Yun Kong and Keesook Lee and Jae Woon Lee},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 10},
  pages={
          3583-92
        }
}
Activating signal cointegrator 2 (ASC-2), a cancer-amplified transcriptional coactivator of nuclear receptors and many other transcription factors, contains two LXXLL-type nuclear receptor interaction domains. Interestingly, the second LXXLL motif is highly specific to the liver X receptors (LXRs). In cotransfection, DN2, an ASC-2 fragment encompassing this motif, exerts a potent dominant-negative effect on transactivation by LXRs, which is rescued by ectopic coexpression of the full-length ASC… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Identification and Characterization of the Alternatively Spliced Nuclear Receptor Coactivator-6 Isoforms

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Molecular determinants of the interactions between LXR/RXR heterodimers and TRAP220.

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2.

VIEW 5 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS

Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2.

  • Daehwan Kim, Janghyun Kim, +5 authors Jae Woon Lee
  • Biology, Medicine
  • Cell reports
  • 2016
VIEW 2 EXCERPTS
CITES BACKGROUND

Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor.

VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 62 REFERENCES

Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.

VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL