Activating omega-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3.

@article{kov2003ActivatingOP,
  title={Activating omega-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3.},
  author={Mark{\'e}ta Ž{\'a}{\vc}kov{\'a} and Eva {\vS}kobisov{\'a} and Eva Urb{\'a}nkov{\'a} and Petr Je{\vz}ek},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 23},
  pages={20761-9}
}
UCP2 (the lowest Km values: 20 and 29 microm, respectively) for omega-6 polyunsaturated FAs (PUFAs), all-cis-8,11,14-eicosatrienoic and all-cis-6,9,12-octadecatrienoic acids, which are also the most potent agonists of the nuclear PPARbeta receptor in the activation of UCP2 transcription. omega-3 PUFA, cis-5,8,11,14,17-eicosapentaenoic acid had lower affinity (Km, 50 microm), although as an omega-6 PUFA, arachidonic acid exhibited the same low affinity as lauric acid (Km, approximately 200… CONTINUE READING

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