Activating mutations of Gsalpha in kidney cancer.

  title={Activating mutations of Gsalpha in kidney cancer.},
  author={Nicolas Kalfa and Serge Lumbroso and Nathalie Boulle and Jacques Guiter and Laurent Soustelle and Pierre Costa and H{\'e}liette Chapuis and Pierre Baldet and Charles S Sultan},
  journal={The Journal of urology},
  volume={176 3},
PURPOSE Heterotrimeric G proteins are signal transduction proteins coupled to hormone receptors that activate intracellular second messenger systems, mainly cyclic adenosine monophosphate mediated protein kinase. Recent studies indicate that G proteins may have a major role in oncogenesis as well as in tumor invasiveness and cell proliferation. The involvement of G proteins was formerly thought to be limited to hormonal signal transduction. Activating Gsalpha mutations have been reported in… CONTINUE READING


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