Activating mutations of Gsalpha in kidney cancer.

@article{Kalfa2006ActivatingMO,
  title={Activating mutations of Gsalpha in kidney cancer.},
  author={Nicolas Kalfa and Serge Lumbroso and Nathalie Boulle and Jacques Guiter and Laurent Soustelle and Pierre Costa and H{\'e}liette Chapuis and Pierre Baldet and Charles S Sultan},
  journal={The Journal of urology},
  year={2006},
  volume={176 3},
  pages={891-5}
}
PURPOSE Heterotrimeric G proteins are signal transduction proteins coupled to hormone receptors that activate intracellular second messenger systems, mainly cyclic adenosine monophosphate mediated protein kinase. Recent studies indicate that G proteins may have a major role in oncogenesis as well as in tumor invasiveness and cell proliferation. The involvement of G proteins was formerly thought to be limited to hormonal signal transduction. Activating Gsalpha mutations have been reported in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

GNAS Mutation Affecting Codon 201 is Rare in Most Human Tumors

Pathology & Oncology Research • 2015
View 4 Excerpts
Highly Influenced

Increased Risk of Breast Cancer at a Young Age in Women with Fibrous Dysplasia.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…