Activating mutations in human acute megakaryoblastic leukemia.

  title={Activating mutations in human acute megakaryoblastic leukemia.},
  author={S{\'e}bastien Malinge and Christine Ragu and V{\'e}ronique Della-Valle and Didier F Pisani and Stefan N Constantinescu and Christelle P{\'e}rez and J L Villeval and Dirk Reinhardt and Judith Landman-Parker and Lucienne Michaux and Nicole Dastugue and Andr{\'e} Baruchel and William Vainchenker and Jean-Pierre Bourquin and Virginie Penard-Lacronique and Olivier Adrien Bernard},
  volume={112 10},
Oncogenic activation of tyrosine kinase signaling pathway is recurrent in human leukemia. To gain insight into the oncogenic process leading to acute megakaryoblastic leukemia (AMKL), we performed sequence analyses of a subset of oncogenes known to be activated in human myeloid and myeloproliferative disorders. In a series of human AMKL samples from both Down syndrome and non-Down syndrome patients, mutations were identified within KIT, FLT3, JAK2, JAK3, and MPL genes, with a higher frequency… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
68 Extracted Citations
37 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 68 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 37 references

Mutations of JAK2, JAK3 and GATA1 in acute megakaryoblastic leukemia of Down syndrome

  • A Hama, H Yagasaki, Y Takahashi, K Matsumoto, H Kiyoi, S. Kojima
  • Blood
  • 2008

Collaboration between activating mutations in JAK2 and trisomy 21 in the acute lymphoblastic leukemias of Down syndrome (DS) [abstract

  • I Ganmore, D Bercovich, LM Scott
  • Blood
  • 2007

Loss-offunction JAK3 mutations in TMD and AMKL of Down syndrome

  • S De Vita, C Mulligan, S McElwaine
  • Br J Haematol
  • 2007

Similar Papers

Loading similar papers…