Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias


Activating mutations in NOTCH1 are found in over 50% of human T-cell lymphoblastic leukemias (T-ALLs). Here, we report the analysis for activating NOTCH1 mutations in a large number of acute myeloid leukemia (AML) primary samples and cell lines. We found activating mutations in NOTCH1 in a single M0 primary AML sample, in three (ML1, ML2 and CTV-1) out of… (More)
DOI: 10.1038/sj.leu.2404409


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