Activating mutations in ALK provide a therapeutic target in neuroblastoma

@article{George2008ActivatingMI,
  title={Activating mutations in ALK provide a therapeutic target in neuroblastoma},
  author={Rani E. George and Takaomi Sanda and Megan Hanna and Stefan Fr{\"o}hling and William Luther and Jianming Zhang and Yebin Ahn and Wenjun Zhou and Wendy B. London and Patrick W. McGrady and Liquan Xue and Sergey Zozulya and Vladim{\'i}r Gregor and Thomas R. Webb and Nathanael S. Gray and Dwight Gary Gilliland and Lisa R Diller and Heidi Greulich and Stephan W. Morris and Matthew L Meyerson and A. Thomas Look},
  journal={Nature},
  year={2008},
  volume={455},
  pages={975 - 978}
}
Neuroblastoma, an embryonal tumour of the peripheral sympathetic nervous system, accounts for approximately 15% of all deaths due to childhood cancer. High-risk neuroblastomas are rapidly progressive; even with intensive myeloablative chemotherapy, relapse is common and almost uniformly fatal. Here we report the detection of previously unknown mutations in the ALK gene, which encodes a receptor tyrosine kinase, in 8% of primary neuroblastomas. Five non-synonymous sequence variations were… 

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