Activating mitochondrial function and haemoglobin expression with EH-201, an inducer of erythropoietin in neuronal cells, reverses memory impairment

@article{Horng2015ActivatingMF,
  title={Activating mitochondrial function and haemoglobin expression with EH-201, an inducer of erythropoietin in neuronal cells, reverses memory impairment},
  author={L. Horng and Pei-Lun Hsu and Li-Wen Chen and Wang-Zou Tseng and Kai-Tin Hsu and Chia-ling Wu and Rong-Tsun Wu},
  journal={British Journal of Pharmacology},
  year={2015},
  volume={172},
  pages={4741 - 4756}
}
Memory impairment can be progressive in neurodegenerative diseases, and physiological ageing or brain injury, mitochondrial dysfunction and oxidative stress are critical components of these issues. An early clinical study has demonstrated cognitive improvement during erythropoietin treatment in patients with chronic renal failure. As erythropoietin cannot freely cross the blood–brain barrier, we tested EH‐201 (2,3,5,4′‐tetrahydroxystilbene‐2‐O‐β‐d‐glucoside, also known as TSG), a low MW inducer… Expand
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