Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against β-amyloid peptide-induced human endothelial cells apoptosis.

@article{Yan2013ActivatingGR,
  title={Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against $\beta$-amyloid peptide-induced human endothelial cells apoptosis.},
  author={Jie-ping Yan and Qi-Bing Liu and Y. Dou and Y. Hsieh and Y. Liu and R. Tao and Danyan Zhu and Y. Lou},
  journal={Journal of ethnopharmacology},
  year={2013},
  volume={147 2},
  pages={
          456-66
        }
}
The deposition of β-amyloid (Aβ) in neurons and vascular cells of the brain has been characterized in Alzheimer's disease. Ginsenoside Rg1 (Rg1) is an active components in Panax ginseng, a famous traditional Chinese medicines recorded in Compendium of Materia Medica. Present study attempted to evaluate the potential mechanisms of Aβ-mediated insult and the protective effects of Rg1 on human endothelial cells. Rg1 attenuated the Aβ25-35-associated mitochondrial apoptotic events, accompanied by… Expand
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TLDR
It is reported that Rg1 protects primary rat cerebrocortical neurons against β-amyloid peptide injury and ameliorates Aβ₂₅₋₃₁-induced neuronal apoptosis at least in part by two complementary ERα- and GR-dependent downstream pathways. Expand
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TLDR
This study shows for the first time that in the presence of Rg1, GR and fibroblast growth factor receptor-1 (FGFR-1) cooperate to activate a non-genomic signalling cascade that results in angiogenic activity and proposes that Rg 1 could be a novel prototype of nutraceutical that can induce therapeutic angiogenesis. Expand
Ginsenoside-Rg1 Induces Vascular Endothelial Growth Factor Expression through the Glucocorticoid Receptor-related Phosphatidylinositol 3-Kinase/Akt and β-Catenin/T-cell Factor-dependent Pathway in Human Endothelial Cells*
TLDR
It is shown for the first time that Rg1 was a potent stimulator of vascular endothelial growth factor expression in human umbilical vein endothelial cells, and importantly this induction was mediated through a phosphatidylinositol 3-kinase (PI3K)/Akt and β-catenin/T-cell factor-dependent pathway via the GR. Expand
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TLDR
It is suggested that Rg1 could rescue the cell injury by H( 2)O(2) via down-regulation NF-κB signaling pathway as well as Akt and ERK1/2 activation, which put new evidence on the neuroprotective mechanism of Rg 1 against the oxidative stress and the regulatory role of H(2). Expand
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TLDR
It is demonstrated that Rg1 can reduce the production of Abeta(1-42) and the activation of caspase-3, as a result, to attenuate the cell apoptosis and improve viability in cells injured by Abeta (25-35), inhibit the intracellular Abeta-induced apoptosis in mutant PS1 M146L cells. Expand
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TLDR
The results suggest that Rg1 not only increases IGF‐IR expression but also enhances IGF‐ IR‐mediated signaling pathways in MCF‐7 cells. Expand
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TLDR
It is suggested that NO production increased via ginsenoside Rg1 played an important role in the protective effect on TNF-alpha stimulated HUVECs and was helpful to deeply understand the active mechanism of ginseno-based drugs to HUV ECs at the molecular level. Expand
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