Activating alleles of JAK3 in acute megakaryoblastic leukemia.

  title={Activating alleles of JAK3 in acute megakaryoblastic leukemia.},
  author={Denise Katherine Walters and Thomas Mercher and Ting-lei Gu and Thomas O'Hare and Jeffrey W. Tyner and Marc M. Loriaux and Valerie L Goss and Kimberly A. Lee and Christopher A. Eide and Matthew J. Wong and Eric P. Stoffregen and Laura S. McGreevey and Julie Nardone and Sandra A. Moore and John D. Crispino and Titus J Boggon and Michael C Heinrich and Michael Werner Nikolaus Deininger and Roberto D. Polakiewicz and Dwight Gary Gilliland and Brian J. Druker},
  journal={Cancer cell},
  volume={10 1},
Tyrosine kinases are aberrantly activated in numerous malignancies, including acute myeloid leukemia (AML). To identify tyrosine kinases activated in AML, we developed a screening strategy that rapidly identifies tyrosine-phosphorylated proteins using mass spectrometry. This allowed the identification of an activating mutation (A572V) in the JAK3 pseudokinase domain in the acute megakaryoblastic leukemia (AMKL) cell line CMK. Subsequent analysis identified two additional JAK3 alleles, V722I and… CONTINUE READING
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