Activating Transcription Factor 3 Deficiency Promotes Cardiac Hypertrophy, Dysfunction, and Fibrosis Induced by Pressure Overload

@inproceedings{Zhou2011ActivatingTF,
  title={Activating Transcription Factor 3 Deficiency Promotes Cardiac Hypertrophy, Dysfunction, and Fibrosis Induced by Pressure Overload},
  author={Heng Zhou and Di-fei Shen and Zhou-yan Bian and Jing Zong and Wei Deng and Yan Zhang and Yuan-yuan Guo and Hongliang Li and Qi-Zhu Tang},
  booktitle={PloS one},
  year={2011}
}
Activating transcription factor 3 (ATF3), which is encoded by an adaptive-response gene induced by various stimuli, plays an important role in the cardiovascular system. However, the effect of ATF3 on cardiac hypertrophy induced by a pathological stimulus has not been determined. Here, we investigated the effects of ATF3 deficiency on cardiac hypertrophy using in vitro and in vivo models. Aortic banding (AB) was performed to induce cardiac hypertrophy in mice. Cardiac hypertrophy was estimated… CONTINUE READING
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